Preferred Label : Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10;
NCIt synonyms : Astatine At 211 MAb BC8-B10; At 211 MAb BC8-B10; Astatine 211-Labeled Anti-CD45 Monoclonal Antibody BC8-B10; At 211 Anti-CD45 Monoclonal Antibody BC8-B10;
NCIt related terms : APAMISTAMAB-B10-ASTATINE AT-211;
NCIt definition : A radioimmunoconjugate containing the murine IgG1 anti-CD45 monoclonal antibody (MAb)
BC8 where the lysine side groups have been conjugated with decaborate (closo-decaborate;
B10) and labeled with astatine (At) 211, with potential immunotherapeutic activity.
Astatine At 211 anti-CD45 monoclonal antibody BC8-B10 binds to CD45 antigen, a receptor
protein-tyrosine phosphatase expressed on the surface of both normal and malignant
hematopoietic cells. After binding and internalization by CD45-expressing tumor cells,
this agent may deliver a cytotoxic dose of alpha radiation. Additionally, the radiolabel
can be leveraged to assay the biodistribution and/or pharmacokinetics (absorption,
distribution, metabolism and excretion) for this agent. The use of B10 rather than
other labeling methods increases the therapeutic efficacy while decreasing the toxicity
of the radioconjugate.;
UNII : 3BVH1ZF9JX;
NCI Metathesaurus CUI : CL520581;
Origin ID : C133190;
UMLS CUI : C4524460;
Semantic type(s)
- concept_is_in_subset
- has_target
