Preferred Label : Fluorine F 18 alphaVbeta6-Binding Peptide;
NCIt synonyms : Fluorine F 18-alphaVbeta6-Binding-Peptide; 18F-alphaVbeta6-Binding-Peptide; 18F-aVb6-BP; 18F-alphaVbeta6-Binding Peptide;
NCIt definition : A radiotracer composed of a 20 amino acid peptide derived from the GH loop of an envelope
protein (VP1) of the foot-and-mouth disease virus (FMDV), where the N-terminal lysine
has been substituted with arginine, conjugated with two polyethylene glycol units
and radiolabeled with fluorine 18, for potential positron emission tomography (PET)
imaging of alphaVbeta6 integrin expression. Upon administration, the arginine-glycine-aspartic
acid (RGD) motif within the peptide moiety of the fluorine 18 F alphaVbeta6-binding
peptide selectively binds to alphaVbeta6 integrin. During PET imaging, alphaVbeta6-expressing
tumor cells can be visualized and the degree of tumor growth can be determined. AlphaVbeta6
integrin, a cell adhesion and signaling receptor, is upregulated in certain cancers
and has been associated with proliferation, migration and invasion of tumor cells.;
NCI Metathesaurus CUI : CL520657;
Origin ID : C133094;
UMLS CUI : C4524378;
Semantic type(s)
- concept_is_in_subset
- has_target
