Preferred Label : CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes;
NCIt synonyms : CD19R(EQ)28zetaEGFRt Tn/mem Cells; CD19R(EQ)28zeta/EGFRt Naive and Memory T Cells; CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T Cells;
NCIt definition : A preparation of genetically modified lymphocytes comprised of CD62L-positive naïve
and memory T-cells (Tn/mem), that are transduced ex vivo with a self-inactivating
(SIN) lentiviral vector expressing a hinge-optimized chimeric antigen receptor (CAR)
specific for the CD19 antigen and containing CD28 and CD3 zeta signaling domains,
and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential
immunostimulating and antineoplastic activities. Upon isolation of peripheral blood
lymphocytes (PBLs), transduction of the CD62L-positive T-lymphocytes, expansion ex
vivo and administration, the CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched
T-cells target CD19-expressing tumor cells, thereby inducing selective toxicity in
CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen
expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains
and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered
T-cells and can promote elimination of those cells upon a cetuximab-induced antibody
dependent cellular cytotoxicity response. Tn/mem T-cells include naïve T-cells, central
memory T-cells (Tcm) and stem cell memory T-cells (Tscm). CD19R(EQ) contains two point
mutations in the immunoglobulin (Ig) G4 spacer region, thereby preventing recognition
of the CAR by Fc receptors (FcRs).;
NCI Metathesaurus CUI : CL519704;
Origin ID : C133073;
UMLS CUI : C4522300;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
