Preferred Label : CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes;
NCIt synonyms : CD19R(EQ)28zeta/EGFRt TCM; CD19R:CD28:lentiviral/EGFRt T Cells; CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T Cells; CD19R(EQ)28zeta/truncated Human EGFR Central Memory T Cells; CD19-CAR-specific/truncated EGFR Lentiviral Vector-transduced T Cells;
NCIt definition : A preparation of genetically modified central memory (Tcm) enriched T-cells transduced
with a replication incompetent lentiviral vector expressing a chimeric antigen receptor
(CAR), containing a CD28 signaling domain fused to both CD3 zeta, which targets the
CD19 antigen, and a truncated form of the human epidermal growth factor receptor (EGFRt),
with potential immunostimulating and antineoplastic activities. Upon intravenous administration,
CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells are directed to CD19-expressing
tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells.
CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage
malignancies. Devoid of both ligand binding domains and tyrosine kinase activity,
EGFRt both facilitates in vivo detection of the administered T-cells and can promote
elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity
response. The costimulatory signaling domain enhances proliferation of T cells and
antitumor activity.;
NCI Metathesaurus CUI : CL519703;
Origin ID : C133072;
UMLS CUI : C4524369;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
