Preferred Label : Alrizomadlin;
NCIt synonyms : MDM2-p53 Inhibitor APG-115; p53-HDM2 Protein-protein Interaction Inhibitor APG-115;
NCIt definition : An orally available inhibitor of human homolog of double minute 2 (HDM2; mouse double
minute 2 homolog; MDM2), with potential antineoplastic activity. Upon oral administration,alrizomadlin
binds to HDM2, preventing the binding of the HDM2 protein to the transcriptional activation
domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction,
the proteasome-mediated enzymatic degradation of p53 is inhibited and the transcriptional
activity of p53 is restored. This may result in the restoration of p53 signaling and
lead to the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein
and a negative regulator of the p53 pathway, is often overexpressed in cancer cells.
It has been implicated in cancer cell proliferation and survival.;
UNII : 15QAU0SI9J;
CAS number : 1818393-16-6;
Molecule name : APG 115; APG-115; AA-115;
NCI Metathesaurus CUI : CL520348;
Origin ID : C132991;
UMLS CUI : C5667162;
Semantic type(s)
- concept_is_in_subset
- has_target
