MGMT-Unmethylated Glioblastoma

Preferred Label : MGMT-Unmethylated Glioblastoma;

NCIt synonyms : Unmethylated MGMT Glioblastoma;

NCIt definition : A glioblastoma characterized by the absence of DNA methylation in the promoter region of the MGMT gene. It is associated with a poor outcome.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL520767;

Details

Origin ID

C132902;

UMLS CUI

C4330601;

Disease may have findings
- Headache [NCIt concept]
- Seizure [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Central Nervous System [NCIt concept]
- Nervous System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Precise Histogenesis Unknown [NCIt concept]
disease_excludes_molecular_abnormality
- IDH Gene Family Mutation [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Astrocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Glial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell [NCIt concept]
- Poorly Differentiated Neoplastic Astrocyte [NCIt concept]
disease_has_finding
- Anaplastic Lesion [NCIt concept]
- Diffuse Pattern [NCIt concept]
- High Grade Lesion [NCIt concept]
- Infiltrative Growth Pattern [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Microvascular Proliferation [NCIt concept]
- Mitotic Activity [NCIt concept]
- Necrotic Change [NCIt concept]
- Nuclear Atypia [NCIt concept]
- Primary Lesion [NCIt concept]
- Unmethylated MGMT Gene Promoter [NCIt concept]
disease_has_grade
- Grade 4 [NCIt concept]
- High Grade [NCIt concept]
disease_has_normal_cell_origin
- Astrocyte [NCIt concept]
- Glial Cell [NCIt concept]
- Neuroepithelial Cell [NCIt concept]
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
disease_has_normal_tissue_origin
- Nerve Tissue, Neuroepithelial Tissue, and Nerve Sheaths [NCIt concept]
- Neuroepithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Central Nervous System [NCIt concept]
disease_mapped_to_gene
- EGFR Gene [NCIt concept]
disease_may_have_molecular_abnormality
- EGFR Gene Amplification [NCIt concept]
- EGFR Protein Overexpression [NCIt concept]
- PTEN Gene Inactivation [NCIt concept]

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