Lung Surfactant

Preferred Label : Lung Surfactant;

NCIt synonyms : Surfactant; Surfactant, Lung;

NCIt definition : Pulmonary surfactant lines the lung epithelium and lowers surface tension to prevent collapse at end-expiration. Deficiency of pulmonary surfactant results in respiratory distress syndrome (RDS) in premature infants. Lung surfactant is synthesized in alveolar type II cells, stored in lamellar bodies and secreted via exocytosis.;

Alternative definition : CDISC: Pulmonary surfactant lines the lung epithelium and lowers surface tension to prevent collapse at end-expiration. Deficiency of pulmonary surfactant results in respiratory distress syndrome (RDS) in premature infants. Lung surfactant is synthesized in alveolar type II cells, stored in lamellar bodies and secreted via exocytosis. (NCI);

Details

Origin ID

C13273;

UMLS CUI

C0034085;

Associated anatomy of gene products
- Pulmonary Surfactant-Associated Protein A1 [NCIt concept]
- Pulmonary Surfactant-Associated Protein A2 [NCIt concept]
- Pulmonary Surfactant-Associated Protein B [NCIt concept]
- Pulmonary Surfactant-Associated Protein C [NCIt concept]
- Pulmonary Surfactant-Associated Protein D [NCIt concept]
Automatic exact mappings (from CISMeF team)
- Respiratory surfactant (product) [Inactive SNOMED CT concept]
- Surfactant (disposition) [SNOMED CT concept]
- surfactant protein A1 [HGNC gene]
- surfactant protein A2 [HGNC gene]
Currated CISMeF NLP mapping
- Lung surfactant (substance) [SNOMED CT concept]
- Pulmonary surfactant [FMA entity]
- Surfactant [LOINC component]
- Surfactant (substance) [SNOMED CT concept]
- lung surfactant [SNOMED Notion]
- lung surfactants [ATC Code]
- pulmonary surfactant [UBERON concept]
- pulmonary surfactants [MeSH concept]
- pulmonary surfactants [MeSH Descriptor]
- surface-active agents [MeSH Descriptor]
- surfactant [IUPAC Term]
- surfactant, nos [SNOMED Notion]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Lung surfactant (substance) [SNOMED CT concept]
- Pulmonary surfactant [FMA entity]
- Respiratory surfactant (product) [Inactive SNOMED CT concept]
- lung surfactant [SNOMED Notion]
- lung surfactants [ATC Code]
- pulmonary surfactant [UBERON concept]
- pulmonary surfactants [MeSH concept]
- pulmonary surfactants [MeSH Descriptor]
Validated automatic mappings to NTBT
- surfactants [MeSH concept]
anatomic_structure_has_location
- Respiratory System [NCIt concept]
concept_is_in_subset
- CDISC SDTM Specimen Type Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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