NCIt synonyms : Anti-LAG-3 MoAb REGN3767; WHO 11182;
NCIt definition : A monoclonal antibody directed against the inhibitory receptor lymphocyte activation
gene-3 protein (LAG-3; LAG3; CD223), with potential immune checkpoint inhibitory and
antineoplastic activities. Upon administration, fianlimab binds to LAG-3 expressed
by tumor infiltrating lymphocytes (TILs) and blocks LAG-3 binding to tumor cells expressing
major histocompatibility complex (MHC) class II molecules. This may activate antigen-specific
T-lymphocytes and enhance cytotoxic T-lymphocyte (CTL)-mediated tumor cell lysis,
which leads to a reduction in tumor growth. LAG-3, a member of the immunoglobulin
superfamily (IgSF), is expressed on various immune cells; its expression on TILs is
associated with tumor-mediated immune suppression and the negative regulation of both
cellular proliferation and T-cell activation.;
Semantic type(s)