Inactive Rhomboid Protein 2

Preferred Label : Inactive Rhomboid Protein 2;

NCIt synonyms : iRhom2; Rhomboid Veinlet-Like Protein 5; Rhomboid Veinlet-Like Protein 6; Rhomboid 5 Homolog 2; Rhomboid Family Member 2;

NCIt definition : Inactive rhomboid protein 2 (856 aa, 97 kDa) is encoded by the human RHBDF2 gene. This protein plays a role in the modulation of both epidermal growth factor receptor (EGFR) ligand secretion and EGFR-dependent signaling.;

NCIt note : Inactive rhomboid protein 2 shares homology with serine proteinases of the rhomboid family but it does not possess enzymatic activity.;

Details

Origin ID

C132324;

UMLS CUI

C3657556;

Automatic exact mappings (from CISMeF team)
- Rhomboid 5 homolog 2 [OMIM gene]
- rhomboid 5 homolog 2 [ORDO Gene]
- rhomboid 5 homolog 2 [HGNC gene]
OMIM relation
- Rhomboid 5 homolog 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- RHBDF2 protein, human [MeSH Supplementary Concept]
- RHBDF2 protein, human [MeSH concept]
gene_encodes_gene_product
- RHBDF2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_expressed_in_tissue
- Epidermis [NCIt concept]
- Esophageal Epithelium [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Protein Secretion [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients