Preferred Label : Anti-GITR Agonistic Monoclonal Antibody BMS-986156;
NCIt synonyms : TNFRSF18 Agonist BMS-986156; GITR Agonist BMS-986156; Anti-GITR MoAb BMS-986156;
NCIt related terms : BMS-986156;
NCIt definition : An anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR; tumor necrosis
factor superfamily member 18; TNFRSF18; CD357) agonistic monoclonal antibody, with
potential immune checkpoint modulating activity. Anti-GITR antibody BMS-986156 binds
to and activates GITR, which is expressed on the cell surface of multiple types of
T-cells. This stimulates the immune system, induces both the activation and proliferation
of tumor antigen-specific T-effector cells (Teffs), and suppresses the function of
activated T-regulatory cells (Tregs). This leads to tumor cell eradication. GITR,
a member of the TNF receptor superfamily and T-cell receptor co-stimulator, is expressed
on the surface of multiple immune cell types, including Tregs, Teffs, B-cells, and
natural killer (NK) cells. Inappropriately activated Tregs suppress both Teffs and
T-cell receptor (TCR) signaling.;
UNII : V0XQ564M2L;
Molecule name : BMS-986156; BMS 986156;
NCI Metathesaurus CUI : CL507899;
Origin ID : C132267;
UMLS CUI : C4329325;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
