NCIt synonyms : Anti-PD-1 Monoclonal Antibody BI 754091;
NCIt definition : A monoclonal antibody directed against the negative immunoregulatory human cell surface
receptor programmed cell death protein 1 (PD-1; PDCD1), with immune checkpoint inhibitory
and antineoplastic activities. Upon administration, ezabenlimab selectively binds
to and blocks the activation of PD-1, an immunoglobulin (Ig) superfamily transmembrane
protein, by its ligands programmed cell death ligand 1 (PD-L1), which is overexpressed
on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily
expressed on antigen-presenting cells (APCs). This results in the activation of T-cells
and T-cell-mediated immune responses against tumor cells. Activated PD-1 negatively
regulates T-cell activation and plays a key role in in tumor evasion from host immunity.;
Semantic type(s)