Preferred Label : Gallium Ga 68-NODAGA-ZIGF-1R:4:40;
NCIt synonyms : 68Ga-NODAGA-ZIGF-1R:4:40; [68Ga]-labeled Anti-IGF-1R Affibody Molecule ZIGF-1R:4:40;
NCIt definition : A radiolabeled recombinant insulin-like growth factor 1 receptor (IGF-1R; IGF1R)-specific
affibody ligand composed of an IGF1R-targeting protein, the anti-IGF1R affibody ZIGF-1R:4:40
with an acetylated cysteine (Ac-Cys) at the N terminal of the affibody, that is site-specifically
conjugated with the chelating agent NODAGA (1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic
acid), and labeled with the radioisotope gallium Ga 68, with potential use for imaging
IGF1R-expressing tumor cells upon positron emission tomography (PET). Upon administration
of gallium Ga 68-NODAGA-ZIGF-1R:4:40, the ZIGF-1R:4:40 affibody molecule moiety targets
and binds to IGF1R expressed on various tumor cell types. Upon PET, IGF1R-expressing
tumor cells can be visualized. IGF1R, frequently overexpressed in cancers, plays important
roles in cell proliferation, survival, adhesion, migration, and differentiation. The
affibody protein scaffold is based on the Z-domain, which is derived from one of the
immunoglobulin (Ig) G-binding domains of staphylococcal protein A.;
NCI Metathesaurus CUI : CL520665;
Origin ID : C132030;
UMLS CUI : C4330034;
Semantic type(s)
- concept_is_in_subset
- has_target
