A-DNA - CISMeF

Preferred Label : A-DNA;

NCIt synonyms : A-Form DNA;

NCIt definition : A-DNA is a shorter and wider helix than B-DNA. Most RNA and RNA-DNA duplex are in this form. While deep, narrow major groove is not easily accessible to proteins but wide, shallow minor groove is accessible to proteins but with lower information content than major groove. A-DNA is the favored conformation at low water concentrations. Base pairs are tilted to helix axis and displaced from axis and sugar pucker is C3'-endo (in RNA 2'-OH inhibits C2'-endo conformation). When examined from the top of the helix, there is a large hole in the middle, the sugar phosphate backbone is at the edge of the helix, and the bases are displaced towards the edge.;

Details

Origin ID

C13186;

UMLS CUI

C0000702;

Automatic exact mappings (from CISMeF team)
- 5'-amino-5'-deoxy-5'-noraristeromycin [MeSH Supplementary Concept]
- DNA [IUPAC Term]
- DNA [MeSH concept]
- DNA [MeSH Descriptor]
- Deoxyribonucleic acid (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- DNA, A-Form [MeSH concept]
- DNA, A-form [MeSH Descriptor]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
UMLS correspondences (same concept)
- DNA, A-Form [MeSH concept]
- DNA, A-form [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

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