Preferred Label : Bomedemstat;
NCIt synonyms : Lysine-specific Demethylase 1 Inhibitor IMG-7289; LSD-1 Inhibitor IMG-7289;
NCIt definition : An orally available, irreversible inhibitor of lysine-specific demethylase 1 (LSD1),
with potential antineoplastic activity. Upon administration, bomedemstat binds to
and inhibits LSD1, a demethylase that suppresses the expression of target genes by
converting the di- and mono-methylated forms of lysine at position 4 of histone H3
(H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and
increases the expression of tumor suppressor genes. In addition, LSD1 demethylates
mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes;
thus, inhibition of LSD1 also promotes H3K9 methylation and decreases transcription
of these genes. Altogether, this may lead to an inhibition of cell growth in LSD1-overexpressing
tumor cells. LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent
amine oxidase family is overexpressed in certain tumor cells and plays a key role
in the regulation of gene expression, tumor cell growth and survival.;
UNII : Y2T4ALDEAT;
InChIKey : KQKBMHGOHXOHTD-KKUQBAQOSA-N;
CAS number : 1990504-34-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1990504-34-1
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : IMG 7289; IMG-7289;
NCI Metathesaurus CUI : CL514400;
Origin ID : C131827;
UMLS CUI : C5418180;
Semantic type(s)
- concept_is_in_subset
- has_target
