NCIt definition : A humanized immunoglobulin (Ig) G1 monoclonal antibody (mAb) against C-X-C chemokine
receptor type 4 (CXCR4), with potential antineoplastic activity. Upon administration,
anti-CXCR4 mAb PF-06747143 binds to CXCR4, thereby preventing the binding of stromal
cell-derived factor-1 (SDF-1 or CXCL12) to CXCR4 and inhibiting CXCR4 activation.
This results in decreased proliferation and migration of CXCR4-expressing tumor cells.
In addition, PF-06747143 promotes cell death through the induction of both complement-dependent
cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). CXCR4, a chemokine
receptor belonging to the G protein-coupled receptor (GPCR) family, is upregulated
in several tumor cell types and plays an important role in cancer cell proliferation,
survival, and chemotaxis, and in tumor angiogenesis.;
Semantic type(s)