Preferred Label : CXCR4 Antagonist USL311;
NCIt synonyms : CXCR4 Inhibitor USL311;
NCIt related terms : USL-311;
NCIt definition : An orally bioavailable inhibitor of C-X-C chemokine receptor type 4 (CXCR4), with
potential antineoplastic activity. Upon administration, USL311 binds to CXCR4, thereby
preventing the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4
and inhibiting CXCR4 activation, which may result in decreased proliferation and migration
of CXCR4-expressing tumor cells. CXCR4, a chemokine receptor belonging to the G protein-coupled
receptor (GPCR) family, plays an important role in chemotaxis and angiogenesis, and
is upregulated in several tumor cell types.;
UNII : 2BTG5MX2Q2;
CAS number : 1373268-67-7;
Molecule name : USL 311; USL311;
NCI Metathesaurus CUI : CL514455;
Origin ID : C131534;
UMLS CUI : C4329607;
Semantic type(s)
- concept_is_in_subset
- has_target
