Alternative definition : NICHD: An autosomal dominant or recessive form of craniotubular hyperostosis due to
mutation(s) in the SOST gene, encoding sclerostin. This condition is characterized
by massive generalized hyperostosis and sclerosis, especially involving the skull
and facial bones, which is so severe that the resulting facial distortion is referred
to as 'leontiasis ossea'; the bone deposition results in progressive stenosis of craniofacial
foramina and can lead to severe neurologic impairment in childhood.;