" /> Toripalimab - CISMeF





Preferred Label : Toripalimab;

NCIt synonyms : Anti-PD-1 Monoclonal Antibody JS001; Toripalimab-tpzi;

NCIt definition : A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (programmed death-1; PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, toripalimab binds to PD-1 and inhibits the binding of PD-1 to its ligands, programmed cell death-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of both T-cells and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the Ig superfamily that is expressed on activated T-cells, negatively regulates T-cell activation and effector function when activated by its ligands; it plays an important role in tumor evasion from host immunity.;

UNII : 8JXN261VVA;

CAS number : 1924598-82-2;

Drug name : Tuoyi; Loqtorzi;

Molecule name : TAB 001; TAB-001; JS 001; JS-001;

NCI Metathesaurus CUI : CL514245;

Codes from synonyms : 64471;

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31/05/2025


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