" /> Pulrodemstat - CISMeF





Preferred Label : Pulrodemstat;

NCIt synonyms : Lysine-specific Demethylase 1 Inhibitor CC-90011; LSD1 Inhibitor CC-90011;

NCIt definition : An orally available inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, pulrodemstat binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor (remove hyphen) suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes; inhibition of LSD1 promotes H3K9 methylation and decreases transcription of these genes. LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent amine oxidase family that is overexpressed in certain tumor cells, plays a key role in tumor cell growth and survival.;

UNII : W6F4FRQ5QC;

CAS number : 1821307-10-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1821307-10-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CC 90011; CC-90011;

NCI Metathesaurus CUI : CL514523;

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14/05/2024


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