Preferred Label : Anti-CSF1 Monoclonal Antibody PD-0360324;
NCIt synonyms : Anti-M-CSF mAb PD-0360324;
NCIt related terms : PD-0360324;
NCIt definition : A humanized immunoglobulin (Ig) G2 monoclonal antibody (mAb) directed against the
cytokine colony stimulating factor 1 (CSF1; CSF-1; macrophage colony-stimulating factor;
M-CSF), with potential immunomodulating and antineoplastic activities. Upon administration,
anti-CSF1 monoclonal antibody PD-0360324 targets, binds to and neutralizes CSF1. This
prevents the binding of CSF1 to its receptor CSF1R (CD115; M-CSFR), which is expressed
on various immune cells, such as monocytes and macrophages. This prevents CSF1R activation
and CSF1R-mediated signaling in these cells; this inhibits monocyte differentiation,
blocks the activity of macrophages, and reduces their production of inflammatory mediators,
which reduces inflammation. By blocking the activity and proliferation of CSF1R-dependent
tumor-associated macrophages (TAMs) in the tumor microenvironment, PD-0360324 reduces
TAM-mediated immune suppression, decreases regulatory T-cells (Tregs), re-activates
the immune system, and improves anti-tumor cell responses mediated by increasing infiltration
by cytotoxic T-cells. TAMs play key roles in immune suppression, and tumor cell proliferation
and survival. CSF-1 plays a key role in the regulation of the proliferation, differentiation
and survival of monocytes and macrophages.;
UNII : EF7PK2TQ0U;
CAS number : 1822383-05-0;
Molecule name : PD-360,324; PD-0360324; PD 360324; PD 0360324;
NCI Metathesaurus CUI : CL514242;
Origin ID : C131301;
UMLS CUI : C4329319;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
