Preferred Label : Montanide ISA-51 VG/KLH/NY-ESO-1/MART-1 Peptide Vaccine;
NCIt synonyms : NY-ESO-1/MART-1/KLH/Montanide ISA-51 VG Vaccine; Montanide ISA-51 VG/KLH/NY-ESO-1/MART-1 Vaccine;
NCIt definition : A cancer vaccine consisting of two immunogenic peptides derived from the cancer-testis
antigen NY-ESO-1 and the melanoma differentiation antigen Melan-A (MART-1; Melanoma
Antigen Recognized by T-cells 1), which are conjugated with the immunostimulant keyhole
limpet hemocyanin (KLH) and emulsified in the immunoadjuvant Montanide ISA-51 VG,
with potential immunomodulating and antineoplastic activities. Upon subcutaneous vaccination,
the Montanide ISA-51 VG/KLH/NY-ESO-1/MART-1 peptide vaccine stimulates the host immune
system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing
the NY-ESO-1 and Melan-A antigens, resulting in tumor cell lysis. NY-ESO-1 and Melan-A
are overexpressed in a variety of tumor cell types. The surfactant mannide monooleate
in Montanide ISA 51 VG is derived from vegetable-grade (VG) oleic acid that was purified
from olive oil. KLH is a hapten carrier and serves as an immunostimulant to improve
immune recognition.;
NCI Metathesaurus CUI : CL513488;
Origin ID : C131215;
UMLS CUI : C4330707;
Semantic type(s)
- concept_is_in_subset
- has_target
