PEG-interleukin-2

Preferred Label : PEG-interleukin-2;

NCIt synonyms : Polyethylene Glycol-Modified Recombinant Interleukin-2; PEG-IL-2;

NCIt definition : A complex of polyethylene glycol conjugated with human recombinant cytokine interleukin-2 (IL-2) with antineoplastic activity. PEG-interleukin-2 induces natural killer (NK) cell activity and the production of interferon-gamma (IFN-gamma), and enhances T cell-mediated cytotoxicity. Pegylation of IL-2 protects the cytokine from degradation. (NCI04);

Details

Origin ID

C1304;

UMLS CUI

C0083036;

Automatic exact mappings (from CISMeF team)
- Interleukin 2 [LOINC component]
- Interleukin-2 [MeSH Descriptor]
- interleukin-2, polyethylene glycol-modified [MeSH Supplementary Concept]
- interleukin-2, polyethylene glycol-modified [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- interleukin-2, polyethylene glycol-modified [MeSH concept]
- interleukin-2, polyethylene glycol-modified [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Interleukin-2 Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Gene Regulation Process [NCIt concept]
- Immunopotentiation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Intercellular Communication Induction [NCIt concept]
- Lymphocyte Activation Process [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Interleukin-2/PEG-Interleukin-2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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