NCIt definition : An orally available inhibitor of Bruton's tyrosine kinase (BTK; Bruton agammaglobulinemia
tyrosine kinase), with potential antineoplastic activity. Upon administration, DTRMWXHS-12
inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor
(BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation
of downstream survival pathways. This leads to an inhibition of the growth of malignant
B-cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic
tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role
in the development, activation, signaling, proliferation and survival of B-lymphocytes.;
Semantic type(s)