Preferred Label : IDO1 Inhibitor KHK2455;
NCIt synonyms : IDO-1 Inhibitor KHK2455;
NCIt definition : An orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential
immunomodulating and antineoplastic activities. Upon administration, IDO1 inhibitor
KHK2455 targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan
into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, KHK2455
increases and restores the proliferation and activation of various immune cells, including
dendritic cells (DCs), natural killer (NK) cells, and T-lymphocytes. KHK2455 also
induces increased interferon (IFN) production, and causes a reduction in tumor-associated
regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in
many cancers, may inhibit the growth of IDO1-expressing tumor cells. IDO1, a cytosolic
enzyme responsible for tryptophan catabolism and the conversion of tryptophan into
kynurenine, is overexpressed by a variety of tumor cell types and antigen presenting
cells (APCs); it plays an important role in immunosuppression. Tryptophan depletion
inhibits T-lymphocyte proliferation and activation, and subsequently suppresses the
immune system.;
Molecule name : KHK 2455; KHK2455;
NCI Metathesaurus CUI : CL512931;
Origin ID : C129790;
UMLS CUI : C4330400;
Semantic type(s)
- concept_is_in_subset
- has_target
