Natural Cytotoxicity Receptor Family

Preferred Label : Natural Cytotoxicity Receptor Family;

NCIt synonyms : Natural Cytotoxicity Triggering Receptor; Natural Cytotoxicity Receptor; NCR; NK Cell-Activating Receptor; NCR Family;

NCIt definition : A family of receptors belonging to the immunoglobulin superfamily that are mainly expressed on natural killer (NK) cells. Natural cytotoxicity receptors (NCR) bind to a broad range of ligands derived from microbes, tumors, and endogenous sources. Predominantly, ligand binding leads to the activation of NK cells, which stimulates cell-mediated cytotoxic immune responses, but some ligands may inhibit NK cell activation.;

NCIt note : Humans express three of the natural cytotoxicity receptor family proteins.;

PubMed : 24366519;

Details

Origin ID

C129776;

UMLS CUI

C2350479;

Automatic exact mappings (from CISMeF team)
- Neutrophil migration [OMIM Phenotype]
- magnetic resonance spectroscopy [MeSH Descriptor]
- receptors, natural cytotoxicity triggering [MeSH concept]
- receptors, natural cytotoxicity triggering [MeSH Descriptor]
- receptors, natural killer cell [MeSH Descriptor]
Biochemical function of gene products
- Natural Cytotoxicity Triggering Receptor 1 [NCIt concept]
- Natural Cytotoxicity Triggering Receptor 2 [NCIt concept]
- Natural Cytotoxicity Triggering Receptor 3 [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- receptors, natural cytotoxicity triggering [MeSH Descriptor]
- receptors, natural cytotoxicity triggering [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_biochemical_function
- Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients