Preferred Label : BTK Inhibitor TL-895;
NCIt synonyms : Bruton's Tyrosine Kinase Inhibitor M7583;
NCIt definition : An orally bioavailable, selective inhibitor of Bruton's tyrosine kinase (BTK), with
potential antineoplastic activity. Upon oral administration, BTK inhibitor TL-895
targets and covalently binds to BTK, thereby preventing its activity. This leads to
an inhibition of B cell receptor (BCR) signaling and inhibits cell proliferation of
B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family
of kinases, plays an important role in B lymphocyte development, activation, signaling,
proliferation and survival.;
Molecule name : M-7583; TL-895; TL 895; M 7583;
NCI Metathesaurus CUI : CL512935;
Origin ID : C129710;
UMLS CUI : C4329439;
Semantic type(s)
- concept_is_in_subset
- has_target
