" /> 8-Hydroxy-2'-deoxyguanosine - CISMeF





Preferred Label : 8-Hydroxy-2'-deoxyguanosine;

NCIt synonyms : 8-Oxo-dG; 8-OHdG; 8-Oxo-7,8-dihydro-2'-deoxyguanosine; 8-Oxo-2'-Deoxyguanosine; 2-Amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione; 8-Oxo-2 Deoxyguanosine;

NCIt related terms : 8-Hydroxy-2-deoxyguanosine;

NCIt definition : A major spontaneous oxidized derivative of 2'-deoxyguanosine and a biomarker of oxidative DNA damage. 8-hydroxy-2'-deoxyguanosine (8-oxo-dG) is formed through the reaction of guanine with reactive oxygen species. Although normally repaired and removed by the base excision repair mechanism, 8-oxo-dG can potentially mispair with deoxyadenine leading to G-to-T transversion mutations, which cause frequent recombinations and single nucleotide polymorphisms (SNPs) in the human genome. The concentration of 8-oxo-dG within a cell is a measurement of oxidative stress and may thus be used to assess the extent of physiological and environmental damage to DNA.;

UNII : 4RGB38T3IB;

CAS number : 88847-89-6;

Chemical formula : C10H13N5O5;

ChEBI ID : CHEBI:40304;

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17/06/2025


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