Preferred Label : Anti-human GITR Monoclonal Antibody AMG 228;
NCIt synonyms : Agonistic GITR Antibody AMG 228;
NCIt definition : An agonistic anti-human glucocorticoid-induced tumor necrosis factor receptor (tumor
necrosis factor receptor superfamily, member 18; TNFRSF18; GITR; CD357) humanized
monoclonal antibody, with potential immune checkpoint modulating activity. Anti-human
GITR monoclonal antibody AMG 228 binds to and activates GITRs found on multiple types
of T-cells. This stimulates the immune system, induces both the activation and proliferation
of tumor-antigen-specific T effector cells (Teffs), and suppresses the function of
activated T regulatory cells (Tregs). This leads to immune-mediated tumor cell eradication
though a cytotoxic T-lymphocyte (CTL) response. GITR, a member of the TNF receptor
superfamily and T-cell receptor co-stimulator, is expressed on the surface of multiple
immune cell types, including Tregs, Teffs, B-cells, and natural killer (NK) cells.
Inappropriately activated Tregs suppress Teffs and suppress T-cell receptor (TCR)
signaling.;
Molecule name : AMG-228; AMG 228;
NCI Metathesaurus CUI : CL512894;
Origin ID : C129694;
UMLS CUI : C4329344;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
