Preferred Label : Gartisertib;
NCIt synonyms : ATR Kinase Inhibitor VX-803;
NCIt definition : An orally available inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase,
with potential antineoplastic activity. Upon oral administration,gartisertib selectively
inhibits ATR activity and blocks the downstream phosphorylation of the serine/threonine
protein kinase CHK1. This prevents ATR-mediated signaling, which results in the inhibition
of DNA damage checkpoint activation, the disruption of DNA damage repair, and the
induction of tumor cell apoptosis. ATR, a serine/threonine protein kinase upregulated
in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression
and survival; it is activated by DNA damage caused during DNA replication-associated
stress.;
UNII : 7OM98IUD1O;
CAS number : 1613191-99-3;
Molecule name : VX 803; VX-803; M 4344; M-4344;
NCI Metathesaurus CUI : CL507788;
Origin ID : C129693;
UMLS CUI : C5667157;
Semantic type(s)
- concept_is_in_subset
- has_target
