" /> Palupiprant - CISMeF





Preferred Label : Palupiprant;

NCIt synonyms : EP4 Inhibitor E7046; Prostaglandin E EP4 Receptor Antagonist E7046; EP4 Antagonist E7046; Prostaglandin E2 EP4 Receptor Inhibitor AN0025;

NCIt definition : An orally bioavailable antagonist of the prostaglandin E2 (PGE2) receptor type 4 (EP4; EP-4), with potential immunomodulating and antineoplastic activities. Upon oral administration, palupiprant selectively targets, binds to and blocks the activity of immunosuppressive tumor-associated myeloid cells (TAMCs) in the microenvironment. This abolishes TAMC-dependent immunosuppression and reduces tumor cell proliferation. The presence of immunosuppressive myeloid cells in certain tumors is associated with a poor prognosis.;

UNII : YWY620GU8I;

CAS number : 1369489-71-3;

Molecule name : E 7046; E-7046; AN 0025; AN-0025; ER-886046;

NCI Metathesaurus CUI : CL507851;

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31/05/2025


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