NCIt definition : An orally bioavailable antagonist of the prostaglandin E2 (PGE2) receptor type 4 (EP4;
EP-4), with potential immunomodulating and antineoplastic activities. Upon oral administration,
palupiprant selectively targets, binds to and blocks the activity of immunosuppressive
tumor-associated myeloid cells (TAMCs) in the microenvironment. This abolishes TAMC-dependent
immunosuppression and reduces tumor cell proliferation. The presence of immunosuppressive
myeloid cells in certain tumors is associated with a poor prognosis.;
UNII : YWY620GU8I;
CAS number : 1369489-71-3;
Molecule name : E 7046; E-7046; AN 0025; AN-0025; ER-886046;