Preferred Label : Phosphorylated Histone H2AX;
NCIt synonyms : Phosphorylated-H2a/x; Phosphorylated-H2A.X; Phospho-H2AX; Phosphorylated Histone H2a/x; Phosphorylated Histone H2A.X; Gamma H2AX; Gamma-H2AX;
NCIt definition : A post-translationally modified form of variant histone H2AX where the serine residue
at position 139 and/or the tyrosine residue at 142 is phosphorylated. Phosphorylation
of serine-139 may be a marker for DNA damage. While phosphorylation or dephosphorylation
of tyrosine-142 appears to affect the recruitment of pro-apoptotic factors or DNA
repair proteins, respectively.;
NCI Metathesaurus CUI : CL512719;
Origin ID : C129645;
UMLS CUI : C4331007;
Semantic type(s)
concept_is_in_subset
related_to_genetic_biomarker