" /> Kynurenine - CISMeF





Preferred Label : Kynurenine;

NCIt synonyms : Kynurenine, L-; 3-Anthraniloyl-L-Alanine; (2S)-2-Amino-4-(2-Aminophenyl)-4-Oxobutanoic Acid; L-Kynurenine; KYN; (S)-Kynurenine;

NCIt definition : A ketone and an amino acid derivative that is synthesized by either tryptophan 2,3-dioxygenase (TDO)- or indoleamine 2,3-dioxygenase (IDO)-mediated oxidation of tryptophan with diverse biological functions, including vasodilatory, immunoregulatory and neuromodulatory activities. Kynurenine is a precursor for niacin. Additionally, kynurenine can be further metabolized into anthranilic acid, kynurenic acid, and 3-hydroxykynurenine; aberrant production of kynurenine is associated with neurological disease-related cognitive deficits and depressive symptoms. Overexpressed in certain cancer cell types, kynurenine could potentially be used as a biomarker to assess cancer risk.;

UNII : 02JW4J5R44;

CAS number : 2922-83-0;

ChEBI ID : CHEBI:16946;

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01/05/2025


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