NCIt definition : A monoclonal antibody directed against the negative immunoregulatory human cell surface
receptor programmed cell death 1 protein (PD-1, PCDC-1), with potential immune checkpoint
inhibitory and antineoplastic activity. Upon administration, cetrelimab binds to PD-1,
and inhibits the interaction with its ligands, programmed cell death 1 ligand 1 (PD-L1,
PD-1L1) and PD-1 ligand 2 (PD-L2, PD-1L2). The inhibition of ligand binding prevents
PD-1-mediated signaling and results in both T-cell activation and the induction of
T-cell-mediated immune responses against tumor cells. PD-1, an immunoglobulin (Ig)
superfamily transmembrane protein and inhibitory receptor, negatively regulates T-cell
activation.;
UNII : LYK98WP91F;
CAS number : 2050478-92-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2050478-92-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Semantic type(s)