Preferred Label : IDO1 Inhibitor PF-06840003;
NCIt synonyms : IDO-1 Inhibitor PF-06840003; Indoleamine 2,3-Dioxygenase Inhibitor PF-06840003;
NCIt related terms : PF-06840003;
NCIt definition : An orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1
(IDO1), with potential immunomodulating and antineoplastic activities. Upon administration,
IDO1 inhibitor PF-06840003 targets and binds to IDO1, an enzyme responsible for the
oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine
in tumor cells, PF-06840003 increases and restores the proliferation and activation
of various immune cells, including dendritic cells (DCs), natural killer (NK) cells,
and T-lymphocytes; PF-06840003 also induces increased interferon (IFN) production,
and causes a reduction in tumor-associated regulatory T cells (Tregs). Activation
of the immune system, which is suppressed in many cancers, may inhibit the growth
of IDO1-expressing tumor cells. IDO1, a cytosolic enzyme responsible for tryptophan
catabolism and the conversion of tryptophan into kynurenine, is overexpressed by a
variety of tumor cell types and antigen presenting cells (APCs); it plays an important
role in immunosuppression. Tryptophan depletion inhibits T-lymphocyte proliferation
and activation, and subsequently suppresses the immune system.;
UNII : 5K1FUI0T2C;
CAS number : 198474-05-4;
Molecule name : PF 06840003; PF-06840003;
NCI Metathesaurus CUI : CL512154;
Origin ID : C129375;
UMLS CUI : C4287721;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
