Preferred Label : Metformin Hydrochloride/Pioglitazone Hydrochloride Extended-Release Tablet;
NCIt synonyms : Metformin HCl/Pioglitazone HCl ER Tablet;
NCIt definition : An extended-release (ER) tablet composed of the hydrochloride salt form of the biguanide
metformin and the hydrochloride salt form of the thiazolidinedione pioglitazone, with
antihyperglycemic activity. Upon oral administration and although the exact mechanism
of action has yet to be fully elucidated, metformin inhibits complex I (NADPH:ubiquinone
oxidoreductase) of the mitochondrial respiratory chain and increases the cellular
AMP to ATP ratio leading to activation of AMP-activated protein kinase (AMPK). This
modulates AMPK-mediated transcription of target genes, which prevents hepatic gluconeogenesis,
decreases intestinal absorption of glucose, enhances insulin sensitivity and fatty
acid oxidation, and increases glucose uptake and utilization in target tissues. Pioglitazone
binds to and activates the transcription factor peroxisome proliferator-activated
receptor gamma (PPAR-gamma), thereby increasing the transcription of insulin-responsive
genes. This enhances insulin sensitivity of insulin-dependent tissues, decreases insulin
resistance, enhances peripheral glucose utilization, and decreases hepatic glucose
output. Altogether, this lowers blood glucose levels.;
Drug name : ACTOplus Met XR;
NCI Metathesaurus CUI : CL512373;
Origin ID : C129316;
UMLS CUI : C5554535;
Semantic type(s)
- concept_is_in_subset
- has_target
