NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the complement
pathway protein C5, with complement pathway inhibitory activity and potential immunomodulating
activity. Upon administration, tesidolumab targets and binds to C5, thereby preventing
both C5 convertase-mediated cleavage of C5 and the formation of C5a and C5b. This
inhibits C5-mediated signal transduction, the formation of the membrane attack complex
(MAC) and the activation of the terminal complement pathway, and results in the prevention
and/or inhibition of both complement-mediated inflammation and cell destruction. C5
plays a key role in the activation of the complement cascade.;
UNII : 3FO6689MSD;
CAS number : 1531594-08-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1531594-08-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;