IDH Gene Family

Preferred Label : IDH Gene Family;

NCIt synonyms : IDH; Isocitrate Dehydrogenase Gene Family;

NCIt definition : A family of genes that encode enzymes that catalyze the decarboxylation of isocitrate yielding alpha-ketoglutarate and carbon dioxide. Alpha-ketoglutarate is a precursor used in the synthesis of alanine, glutamine and pyruvate, and is an important intermediate in the citric acid cycle, which is an essential metabolic pathway used by cells to produce energy through aerobic respiration. Mutations in the IDH1 and IDH2 genes are associated with several types of brain tumors.;

NCI Metathesaurus CUI : CL512151;

Détails

Origin ID

C129260;

UMLS CUI

C4284085;

False automatic mappings
- Infective dermatitis associated with HTLV-1 [ORDO Disease]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_involved_in_molecular_abnormality
- Deleterious IDH1 Gene Mutation [NCIt concept]
- Deleterious IDH2 Gene Mutation [NCIt concept]
- IDH Gene Family Mutation [NCIt concept]
- IDH1 Gene Mutation [NCIt concept]
- IDH1 NM_005896.3:c.356G>A [NCIt concept]
- IDH1 NM_005896.3:c.394C>A [NCIt concept]
- IDH1 NM_005896.3:c.394C>G [NCIt concept]
- IDH1 NM_005896.3:c.394C>T [NCIt concept]
- IDH1 NM_005896.3:c.394_395delinsGT [NCIt concept]
- IDH1 NM_005896.3:c.394_395delinsTC [NCIt concept]
- IDH1 NM_005896.3:c.395G>A [NCIt concept]
- IDH1 NM_005896.3:c.395G>T [NCIt concept]
- IDH1 NM_005896.3:c.395_396inv [NCIt concept]
- IDH2 Gene Mutation [NCIt concept]
- IDH2 NM_002168.3:c.418C>G [NCIt concept]
- IDH2 NM_002168.3:c.418C>T [NCIt concept]
- IDH2 NM_002168.3:c.419G>A [NCIt concept]
- IDH2 NM_002168.3:c.419G>T [NCIt concept]
- IDH2 NM_002168.3:c.514A>G [NCIt concept]
- IDH2 NM_002168.3:c.514A>T [NCIt concept]
- IDH2 NM_002168.3:c.515G>A [NCIt concept]
- IDH2 NM_002168.3:c.515G>T [NCIt concept]
- IDH2 NM_002168.3:c.515_516delinsAA [NCIt concept]
- IDH2 NM_002168.3:c.516G>C [NCIt concept]
- IDH2 NM_002168.3:c.516G>T [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Anaplastic Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted [NCIt concept]
- Astrocytoma, IDH-Mutant [NCIt concept]
- Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted [NCIt concept]
gene_mapped_to_disease
- Anaplastic Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted [NCIt concept]
- Astrocytoma, IDH-Mutant [NCIt concept]
- Astrocytoma, IDH-Mutant, Grade 2 [NCIt concept]
- Astrocytoma, IDH-Mutant, Grade 3 [NCIt concept]
- Astrocytoma, IDH-Mutant, Grade 4 [NCIt concept]
- Gemistocytic Astrocytoma, IDH-Mutant [NCIt concept]
- Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted [NCIt concept]
- Recurrent Astrocytoma, IDH-Mutant [NCIt concept]
- Recurrent Astrocytoma, IDH-Mutant, Grade 3 [NCIt concept]
- Recurrent Astrocytoma, IDH-Mutant, Grade 4 [NCIt concept]
- Recurrent Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted [NCIt concept]
- Unresectable Astrocytoma, IDH-Mutant [NCIt concept]
- Unresectable Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted [NCIt concept]
gene_plays_role_in_process
- Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
genetic_biomarker_related_to
- IDH Family Mutation Analysis Was Not Performed [NCIt concept]
- IDH Family Mutation Analysis Was Performed [NCIt concept]
- IDH Family Wildtype [NCIt concept]
- IDH Gene Family Mutation [NCIt concept]
- IDH Gene Family Mutation Status Unknown [NCIt concept]
- IDH1/2 Mutation Analysis Testing Method [NCIt concept]
- IDH1/2 Mutation Status by Sequencing [NCIt concept]
- IDH1/IDH2 Mutation Analysis [NCIt concept]
- Not Known if IDH Family Mutation Analysis Was Performed [NCIt concept]
- Specify IDH Family Mutation [NCIt concept]
- Was IDH Family Mutation Analysis Performed Question [NCIt concept]
- Was an IDH Family Mutation Identified Question [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

Vous pouvez consulter :

recommendations
documents concerning education
documents for patients