Preferred Label : Simeprevir;
NCIt synonyms : N-(17-(2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo(13.3.0.04,6)octadec-7-ene-4-carbonyl)(cyclopropyl)sulfonamide;
NCIt definition : An orally bioavailable inhibitor of the hepatitis C virus (HCV) protease complex comprised
of non-structural protein 3 and 4A (NS3/NS4A), with activity against HCV genotype
1. Upon administration, simeprevir reversibly binds to the active center and binding
site of the HCV NS3/NS4A protease and prevents NS3/NS4A protease-mediated polyprotein
maturation. This disrupts both the processing of viral proteins and the formation
of the viral replication complex, which inhibits viral replication in HCV genotype
1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavage
of multiple sites within the HCV polyprotein and plays a key role during HCV ribonucleic
acid (RNA) replication. NS4A is an activating factor for NS3. HCV is a small, enveloped,
single-stranded RNA virus belonging to the Flaviviridae family; HCV infection is associated
with the development of hepatocellular carcinoma (HCC).;
UNII : 9WS5RD66HZ;
InChIKey : JTZZSQYMACOLNN-VDWJNHBNSA-N;
CAS number : 923604-59-5;
Drug name : Olysio;
Molecule name : TMC-435; TMC 435; HSDB 8227;
Origin ID : C129015;
UMLS CUI : C2605855;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
