Preferred Label : Cobolimab;
NCIt synonyms : Anti-TIM3 Checkpoint Inhibitor TSR-022; Anti-TIM3 Monoclonal Antibody TSR-022; Immunoglobulin G4, Anti-(Hepatitis A Virus Cellular Receptor 2 (havcr2)) (Humanized
Clone ABT2 Gamma4-chain), Disulfide with Humanized Clone ABT2 Kappa-chain, Dimer;
NCIt definition : A monoclonal antibody against the inhibitory T-cell receptor, T-cell immunoglobulin
and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular receptor
2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, cobolimab binds to TIM-3 expressed on certain T-cells, including
tumor infiltrating lymphocytes (TILs). This abrogates T-cell inhibition, activates
antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis,
which results in a reduction in tumor growth. TIM-3, a transmembrane protein and immune
checkpoint receptor, is associated with tumor-mediated immune suppression.;
UNII : 3K5H4TX2KP;
CAS number : 2022215-65-0;
Molecule name : TSR-022;
NCI Metathesaurus CUI : CL509686;
Origin ID : C128627;
UMLS CUI : C5235388;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
