Preferred Label : Luvixasertib;
NCIt synonyms : TTK Inhibitor CFI-402257; MSP1 Inhibitor CFI-402257; N-cyclopropyl-4-(7-((((1s,3s)-3-hydroxy-3-methylcyclobutyl)methyl)amino)-5-(pyridin-2-yloxy)pyrazolo[1,5-a]pyridin-3-yl)-2-methylbenzamide; Threonine Tyrosine Kinase Inhibitor CFI-402257;
NCIt definition : An orally bioavailable, selective inhibitor of the dual specificity protein kinase
TTK (monopolar spindle 1 kinase, Mps1), with potential antineoplastic activity. Upon
administration, luvixasertib selectively binds to and inhibits the activity of Mps1.
This inactivates the spindle assembly checkpoint (SAC) and accelerates mitosis, which
results in chromosomal misalignment and missegregation, and mitotic checkpoint complex
destabilization. This induces cell death in Mps1-overexpressing cancer cells. Mps1,
a tyrosine and serine/threonine kinase expressed in proliferating normal tissues,
is essential for proper SAC functioning and chromosome alignment. Overexpressed in
various human tumors, Mps1 plays a key role in uncontrolled tumor cell growth.;
UNII : HE97PTK3Q6;
CAS number : 1610759-22-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1610759-22-2
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : CFI-402257;
NCI Metathesaurus CUI : CL507939;
Origin ID : C128288;
UMLS CUI : C5706627;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
