Preferred Label : Pan-AKT Inhibitor ARQ751;
NCIt synonyms : AKT Inhibitor ARQ751;
NCIt definition : An orally bioavailable pan inhibitor of the serine/threonine protein kinase AKT (protein
kinase B) enzyme family with potential antineoplastic activity. Upon oral administration,
AKT inhibitor ARQ 751 selectively binds to and inhibits the activity of the AKT isoforms
1, 2 and 3, which may result in the inhibition of the phosphatidylinositol 3-kinase
(PI3K)/AKT signaling pathway. This may lead to a reduction in tumor cell proliferation
and the induction of tumor cell apoptosis. The AKT signaling pathway is often deregulated
in cancer and is associated with tumor cell proliferation, survival and migration.;
Molecule name : ARQ 751; ARQ751;
NCI Metathesaurus CUI : CL507932;
Origin ID : C128250;
UMLS CUI : C4287680;
Semantic type(s)
- concept_is_in_subset
- has_target
