Preferred Label : Anti-GITR Monoclonal Antibody GWN 323;
NCIt related terms : GWN-323;
NCIt definition : An anti-human glucocorticoid-induced tumor necrosis factor receptor (tumor necrosis
factor superfamily, member 18; TNFRSF18; GITR; CD357) agonistic monoclonal antibody,
with potential immune checkpoint modulating activity. Anti-GITR antibody GWN 323 binds
to and activates GITRs found on multiple types of T-cells. This stimulates the immune
system, induces both the activation and proliferation of tumor-antigen-specific T
effector cells (Teff), and suppresses the function of activated T regulatory cells
(Tregs). This leads to tumor cell eradication. GITR, a member of the TNF receptor
superfamily and T-cell receptor co-stimulator, is expressed on the surface of multiple
immune cell types, including Tregs, Teffs, B-cells, and natural killer (NK) cells.
Inappropriately activated Tregs suppress both Teffs and T-cell receptor (TCR) signaling.;
UNII : WYJ05POC5C;
Molecule name : GWN323; GWN 323;
NCI Metathesaurus CUI : CL507922;
Origin ID : C128028;
UMLS CUI : C4287757;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
