Preferred Label : Microparticle MDP/Bacterial DNA-containing MIS416;
NCIt synonyms : Microparticle MIS416;
NCIt definition : A microparticle combining two immune-modifying components derived from the bacterium
Propionibacterium acnes, a bacterial cell wall component that is rich in muramyl dipeptide
(MDP) and single-stranded bacteria-derived DNA fragments, with potential immunomodulating
and immunoadjuvant activities. Upon administration of MIS416, this agent localizes
in and is taken up mainly by the liver, thereby forming a liver depot. MIS416 is then
taken up by immune cells, such as monocytes and dendritic cells (DCs), where MDP and
the bacterial DNA target and bind to the cytosolic innate pattern recognition receptors
(PRRs) nucleotide-binding oligomerization domain-containing protein 2 (NOD2), and
toll-like receptor 9 (TLR9), respectively. The simultaneous binding and activation
of both NOD2 and TLR9, leads to activation of both NOD2 and TLR9 signaling. This stimulates
the innate immune system, induces secretion of cytokines, particularly interferon
(IFN), and modulates the activation of various immune cells. In the presence of tumor-associated
antigens (TAAs), through simultaneous administration of a TAA-based vaccine, MIS416
modulates T-cell subsets and enhances the cytotoxic T lymphocyte (CTL)-mediated immune
response against TAAs, resulting in an increased anti-tumor immune response. The combination
of NOD2 and TLR9 agonists in MIS416 appears to activate different signaling pathways
as compared to the administration of NOD2 and TLR9 agonists alone.;
Molecule name : MIS 416; MIS-416;
NCI Metathesaurus CUI : CL509275;
Origin ID : C127934;
UMLS CUI : C4287734;
Semantic type(s)
- concept_is_in_subset
- has_target
