Preferred Label : Topoisomerase-1 Inhibitor LMP744;
NCIt synonyms : Indenoisoquinoline LMP744; 5H-(1,3)Dioxolo(5,6)indeno(1,2-C)isoquinoline-5,12(6H)-dione, 6-(3-((2-Hydroxyethyl)amino)propyl)-2,3-dimethoxy-;
NCIt related terms : LMP-744;
NCIt definition : An indenoisoquinoline derivative and topoisomerase 1 (Top1) inhibitor, with potential
antineoplastic activity. Upon administration, LMP744 binds to and stabilizes cleaved
DNA-Top1 complexes, which prevents DNA re-ligation, induces stable, irreversible DNA
strand breaks, prevents DNA repair, and leads to cell cycle arrest and apoptosis.
As tumor cells proliferate at a much higher rate than normal cells, LMP744 specifically
targets cancer cells. Top1, a DNA modifying enzyme essential for transcription, replication,
and repair of double-strand DNA breaks, is overexpressed in tumor cells.;
UNII : 29BY7HQV0T;
InChIKey : QCSDJDQOJBQTDV-UHFFFAOYSA-N;
CAS number : 308246-52-8;
Molecule name : LMP-744;
NCI Metathesaurus CUI : CL509262;
Origin ID : C127900;
UMLS CUI : C4287741;
Semantic type(s)
- concept_is_in_subset
- has_target
