Uterine Corpus High Grade Endometrial Stromal Sarcoma

Preferred Label : Uterine Corpus High Grade Endometrial Stromal Sarcoma;

NCIt synonyms : YWHAE-FAM22 ESS; YWHAE-FAM22 Endometrial Stromal Sarcoma; High Grade ESS; Uterine Corpus High Grade ESS; YWHAE::FAM22 Endometrial Stromal Sarcoma; Endometrial Stromal Sarcoma, High Grade;

NCIt definition : A rare, high grade sarcoma that arises from the endometrial stroma. It is characterized by round cell morphology. It was previously also known as undifferentiated uterine sarcoma. In 2014, high grade endometrial stromal sarcoma was reclassified and is currently considered a distinct and rare neoplasm. It appears to have a prognosis that falls between low grade endometrial stromal sarcoma and undifferentiated sarcoma.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL508195;

Details

Origin ID

C126998;

UMLS CUI

C2239246;

Automatic exact mappings (from CISMeF team)
- uterine diseases [MeSH Descriptor]
Disease excludes normal cell origin
- Epithelial Cell [NCIt concept]
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
Excludes anatomical site(s)
- Bone [NCIt concept]
Has associated anatomic sites
- Connective and Soft Tissue [NCIt concept]
- Corpus Uteri [NCIt concept]
- Endometrial Cavity [NCIt concept]
- Female Reproductive System [NCIt concept]
- Genitourinary System [NCIt concept]
- Reproductive System [NCIt concept]
- Uterus [NCIt concept]
Has cytogenetic abnormalities
- t(10;17)(q22;p13) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Endometrial stromal sarcoma, high grade (morphologic abnormality) [SNOMED CT concept]
- High grade endometrial stromal sarcoma (disorder) [SNOMED CT concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Intermediate Filaments Present [NCIt concept]
- Intracytoplasmic Eosinophilic Inclusion [NCIt concept]
- Pushing Tumor Margin [NCIt concept]
disease_excludes_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Connective and Soft Tissue Cell [NCIt concept]
- Neoplastic Stromal Cell [NCIt concept]
disease_has_finding
- High Grade Lesion [NCIt concept]
- Infiltrating Tumor Margins Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_molecular_abnormality
- YWHAE-FAM22 Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Connective and Soft Tissue Cell [NCIt concept]
- Endometrial Stromal Cell [NCIt concept]
- Endometrioid Stromal Cell [NCIt concept]
- Stromal Cell [NCIt concept]
disease_has_normal_tissue_origin
- Connective and Soft Tissue [NCIt concept]
- Soft Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Corpus Uteri [NCIt concept]
- Female Reproductive System [NCIt concept]
disease_mapped_to_gene
- YWHAE/FAM22 Fusion Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- YWHAE Gene [NCIt concept]
- YWHAE wt Allele [NCIt concept]
- YWHAE/FAM22 Fusion Gene [NCIt concept]

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