Preferred Label : Rineterkib;
NCIt synonyms : ERK Inhibitor LTT462;
NCIt definition : An orally available inhibitor of extracellular signal-regulated kinase (ERK), with
potential antineoplastic activity. Upon oral administration, rineterkib binds to and
inhibits ERK, thereby preventing the activation of ERK-mediated signal transduction
pathways. This results in the inhibition of ERK-dependent tumor cell proliferation
and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated
in numerous tumor cell types and plays a key role in tumor cell proliferation, differentiation
and survival.;
UNII : 15KFN616FK;
InChIKey : YFCIFWOJYYFDQP-PTWZRHHISA-N;
CAS number : 1715025-32-3;
Molecule name : LTT462; LTT 462;
NCI Metathesaurus CUI : CL507900;
Origin ID : C126687;
UMLS CUI : C5446302;
Semantic type(s)
- concept_is_in_subset
- has_target
