Preferred Label : ALK/FAK/Pyk2 Inhibitor CT-707;
NCIt definition : An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma
kinase (ALK), focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2),
with potential antineoplastic activity. Upon administration, ALK/FAK/Pyk2 inhibitor
CT-707 selectively binds to and inhibits ALK , FAK and Pyk2. The inhibition leads
to disruption of ALK- , FAK- and Pyk2-mediated signal transduction pathways and eventually
inhibits tumor cell growth in ALK-, FAK- and Pyk2-overexpressing tumor cells. Expression
of these tyrosine kinases is dysregulated in various tumor types; they play a key
role in tumor cell migration, proliferation, survival, and tumor angiogenesis.;
Molecule name : CT 707; CT-707;
NCI Metathesaurus CUI : CL503764;
Origin ID : C126648;
UMLS CUI : C4287771;
Semantic type(s)
- concept_is_in_subset
- has_target
