Preferred Label : Ragifilimab;
NCIt synonyms : Anti-GITR Agonistic Monoclonal Antibody INCAGN01876;
NCIt definition : An anti-human glucocorticoid-induced tumor necrosis factor receptor (tumor necrosis
factor superfamily, member 18; TNFRSF18; GITR; CD357) agonistic humanized monoclonal
antibody, with potential immune checkpoint modulating activity. Ragifilimab binds
to and activates GITRs found on multiple types of T-cells. This stimulates the immune
system, induces both the activation and proliferation of tumor-antigen-specific T
effector cells (Teff), and suppresses the function of activated T regulatory cells
(Tregs). This leads to tumor cell eradication. GITR, a member of the TNF receptor
superfamily and T-cell receptor co-stimulator, is expressed on the surface of multiple
immune cell types, including Tregs, Teffs, B-cells, and natural killer (NK) cells.
Inappropriately activated Tregs suppress Teffs and suppress T-cell receptor (TCR)
signaling.;
UNII : O440IW9NHN;
CAS number : 2207590-51-8;
Molecule name : INCAGN01876; INCAGN 1876; INCAGN 01876; INCAGN-1876;
NCI Metathesaurus CUI : CL503760;
Origin ID : C126643;
UMLS CUI : C5418175;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
