Leu-Enkephalin

Preferred Label : Leu-Enkephalin;

NCIt synonyms : YGGPL; Tyr-Gly-Gly-Phe-Leu;

NCIt definition : Leu-enkephalin (5 aa, 1 kDa) is encoded by the human PENK gene. This protein is involved in the activation of mu and delta opioid receptors.;

NCIt note : Proenkephalin-A has one sequence that can be cleaved to release Leu-enkephalin. (UniProt);

Details

Origin ID

C126499;

UMLS CUI

C4285073;

Automatic exact mappings (from CISMeF team)
- Leucine enkephalin (substance) [SNOMED CT concept]
- Leucine-enkephalin [LOINC component]
- enkephalin, leucine [MeSH Descriptor]
- prodynorphin [ORDO Gene]
- prodynorphin [HGNC gene]
OMIM relation
- Proenkephalin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- PENK Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Nociception [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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