Preferred Label : PE/HPV16 E7/KDEL Fusion Protein/GPI-0100 TVGV-1;
NCIt synonyms : PE-E7-KDEL/GPI-0100 TVGV-1; TVGV-1 Vaccine; PEK Fusion Protein/GPI-0100 Vaccine;
NCIt definition : A fusion protein consisting of a peptide sequence of human papillomavirus (HPV) type
16 E7 nuclear protein and fused to the Pseudomonas aeruginosa exotoxin A (PE) and
a endoplasmic reticulum (ER) retention signal (KDEL), with potential antineoplastic
activity. Upon administration of PE/HPV16 E7/KDEL fusion protein TVGV-1, the PE moiety
binds to CD91 (LRP1) expressed on a variety of cells, including antigen-presenting
cells such as dendritic cells (DCs), which facilitates the internalization, through
endocytosis, of TVGV-1. Following endocytosis, this agent is proteolytically cleaved
by the proteasome and the epitopes from the HPV E7 protein become bound to MHC-I molecules
and are presented on the DC-cell surface. This facilitates a cytotoxic T-cell- mediated
immune response against HPV16 E7 expressing-tumor cells. KDEL targets the fusion protein
to the ER, which increases this agent's potential to be bound by MHC-I molecules;
this increases the immune response against HPV16 E7-expressing cancer cells.;
Molecule name : TVGV-1;
NCI Metathesaurus CUI : CL504853;
Origin ID : C126276;
UMLS CUI : C5201250;
Semantic type(s)
- concept_is_in_subset
- has_target
